Another interesting study titled "Impact of drug light interval on photodynamic therapy with meta-tetrahydroxyphenylchlorin in malignant mesothelioma" Hans-Beat Ris, Hans Jörg Altermatt, Bernhard Nachbur, J. Charles M. Stewart, Qiang. Wang, Chang Kee Lim, Raymond Bonnett, Ulrich Althaus - International Journal of Cancer Volume 53, Number 1, p. 141-146, 2 January 1993 Here is an excerpt: "Summary - The influence of time interval (TI) between the drug and laser activation on the selectivity meta-tetrahydroxy-phenylchlorin (mTHPC)-mediated photodynamic therapy (PDT) for tumor tissue was evaluated in BALB / c nude mice bearing human malignant mesothelioma xenografts. the following IP administration of 0.3 mg / kg mTHPC, light dose of 10 J / cm2 and 0.1 W/cm2 was delivered at 650 nm in the tumor and the same size area of the hind legs after the fourth I2, 24 and 36 hours, and 2.3, 4.5 and 6 days in groups of 6 animals (surface radiation ). Then, 72 hours after the delivery of light, depth of necrosis was measured in the tumor and the skin and underlying muscle hind legs. Photosensitized necrosis occurred in the normal tissue of the TI with 4 hr 3 days and tumor TI with I2 to 4 GB days. therapeutic ratio of mTHPC-PDT significantly varied with the time interval between the drug and the laser activated, and was the largest in the span of three days. mTHPC concentrations measured in 3 control unirradiated animals at all time points in normal tissues and tumor tissues, and it was found that same in both tissues. the tissue concentration of mTHPC was limited use in relation to the prediction of photosen-sitizing effects in tumor model ."
Another interesting study titled "Impact of drug light interval on photodynamic therapy with meta-tetrahydroxyphenylchlorin in malignant mesothelioma" Hans-Beat Ris, Hans Jörg Altermatt, Bernhard Nachbur, J. Charles M. Stewart, Qiang. Wang, Chang Kee Lim, Raymond Bonnett, Ulrich Althaus - International Journal of Cancer Volume 53, Number 1, p. 141-146, 2 January 1993 Here is an excerpt: "Summary - The influence of time interval (TI) between the drug and laser activation on the selectivity meta-tetrahydroxy-phenylchlorin (mTHPC)-mediated photodynamic therapy (PDT) for tumor tissue was evaluated in BALB / c nude mice bearing human malignant mesothelioma xenografts. the following IP administration of 0.3 mg / kg mTHPC, light dose of 10 J / cm2 and 0.1 W/cm2 was delivered at 650 nm in the tumor and the same size area of the hind legs after the fourth I2, 24 and 36 hours, and 2.3, 4.5 and 6 days in groups of 6 animals (surface radiation ). Then, 72 hours after the delivery of light, depth of necrosis was measured in the tumor and the skin and underlying muscle hind legs. Photosensitized necrosis occurred in the normal tissue of the TI with 4 hr 3 days and tumor TI with I2 to 4 GB days. therapeutic ratio of mTHPC-PDT significantly varied with the time interval between the drug and the laser activated, and was the largest in the span of three days. mTHPC concentrations measured in 3 control unirradiated animals at all time points in normal tissues and tumor tissues, and it was found that same in both tissues. the tissue concentration of mTHPC was limited use in relation to the prediction of photosen-sitizing effects in tumor model ."
Another interesting study titled "Malignant mesothelioma of the pleura:. Clinical aspects and symptomatic treatment," Law MR, Hodson ME, Turner-Warwick M. Here is an excerpt: "Abstract - series of 140 patients with malignant pleural mesothelioma reported clinical presentation was postponed in the case without large effusion, but the tumor is extensive. the presentation, they showed thoracoscopy, thoracotomy, or computed tomography in all patients investigated. thoracoscopy was a useful diagnostic alternative to thoracotomy. with disease progression, mesothelial expansion was more important than distant metastases, which are usually too small and they rarely produce symptoms. skin tumor deposits in areas of previous invasive procedures are not causing pain or other clinical problems, and we believe that diagnostic and therapeutic procedures should not be withheld to avoid them. in the management recurrent pleural effusion, intrapleural bleomycin, preceded by desire, and after vacuuming, a useful alternative to surgery, pneumothorax, spontaneous or iatrogenic, it decortication Adequate pain relief is difficult .. radiation therapy and nerve block procedures were not effective and the drugs are often necessary. "
We all owe debt of gratitude to these fine researchers. If you find any of these statements interesting, please read the study in its entirety.
